Oral Insulin Immune Response Research Could Lead to Vaccine for Type 1 Diabetes

eyesResearchers at the Barbara Davis Center located at the University of Colorado Anschutz Medical Center say that they are one step closer in coming up with the first vaccine for Type 1 diabetes. Type 1 diabetes patients are mostly children and a vaccine could mean that they are no longer sentenced to a life-long battle with diabetes.


In the study the researchers, lead by Dr. Georgeanna Klingensmith, gave children oral insulin on a daily basis. All of the children were deemed to be at high risk of developing Type 1 diabetes. The purpose of the study was to follow children being given oral insulin each day for three to 18 months in order to determine if the presence of the insulin would result in an immune response in the children without causing side-effects.


The findings indicated that for the children that received oral insulin and not just a placebo, roughly 16 percent of the children that received 2.5 mg of insulin per day saw an immune response. Roughly 33 percent of the children that had received a dosage of 7.5 mg of insulin demonstrated an immune response and over 80 percent of the children that were given 67.5 mg of insulin each day showed an immune response.


The researchers say that the findings could help to develop a vaccine for the disease.


The study was published to the Journal of the American Medical Association.

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