Certain People Are Protected From Type 2 Diabetes

A new research study is looking into individuals that are genetically not likely to get diabetes. Diabetes is currently one of the most important public health concerns affecting the world and the United States in particular. There are roughly 29 million Americans that are currently living with diabetes and this figure has shown no signs of decreasing.


As a result, researchers have become increasingly interested in the portion of the population that does not develop diabetes. The latest finding indicates that there is a specific gene mutation that appears to protect people from developing the disease. Researchers from Asia and Europe worked with Mark O. Goodarzi, MD, director of the Division of Endocrinology, Diabetes and Metabolism at Cedars-Sinai Medical Center in order to look at the genes of over 81,000 people that did not have type 2 diabetes. They then compared the genetic information of that with people that have diabetes.


A comparison of the data indicated that there was a mutation in the gene for glucagon-like peptide-1 receptor (GLP1R). This gene mutation appears to protect against Type 2 diabetes by cutting the risk of developing the disease by 14 percent. The computer models created by the researchers indicated that the mutation can result in significant changes to the shape of the receptor, altering functionality.


The mutation is also associated with lowering fasting glucose levels, which can also help to lower the risk of diabetes.

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