New Molecule Found to Prevent Type 1 Diabetes

There is a new finding in the research done by the University of Colorado of Medicine that there is a molecule that is able to stop the growth of type 1 diabetes in mice. By using that molecule to stop growth of type 1 diabetes, they were able to see that it had the same effect on people’s cells that were diabetic. Because of this discovery, it has opened a whole new avenue against fighting diabetes and other autoimmune disease, such as celiac disease, rheumatoid arthritis, and multiple sclerosis. Let’s take a closer at this research done by the University of Colorado of Medicine.

One of the researches, Dr. Eisenbarth, said that they had taken a specific molecule and put it in a specific structural pocket to prevent type 1 diabetes. They had tested several molecules in mice prior to finding this certain one. The molecules actually simulate the presence of insulin while other molecules enhanced the presence of insulin. The problem with Type 1 diabetes is that insulin is not being produced or the body can’t produce insulin for whatever reason. So that is why this molecule that simulates the presence of insulin is so important. If the body can see that there is insulin, then that disease might be not formed.

The name of the compound that was found to prevent diabetes in mice is Glyphosine and Glyphosine enhances the presence of insulin. And when it was tested in human cells, it had the same effect that it did on the mice. The mice had to receive daily injections of Glyphosine to remain free of the disease. But the problem with it is, if the mice had diabetes prior, it didn’t work as well.

Dr. Eisenbarth with the University of Colorado of Medicine, worked closely with the Dr. Ostrov from the University of Florida, College of Medicine in Gainesville to obtain the molecules for the research. Dr. Ostrov said their role was identifying various drug candidates that prevent type 1 diabetes. Therefore, they developed a screening method that identifies the certain area within the protein which is associated with type 1 diabetes.

His lab tested 139,735 various drug candidates to find the ones that would bind to the vital pockets of the protein. It revealed to them that they might be able to change various responses of the immune system for other autoimmune diseases also, such as cancer and other infectious diseases.

Based on all this research, they might be able to start screening individuals’ genes to see if they have the chance to develop type 1 diabetes. If so, they can start some molecule therapy to prevent the disease. Currently, doctors can accurately predict 90% of the time that a person has type 1 diabetes.

The principles are alike with celiac disease and arthritis and other autoimmune disorders. They are hoping that they can use the same molecule therapy on these disorders also. They are working on developing these plans and being able to use them but its still 5 years away.

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