Gastric Bypass Surgery Effective In Diabetic Patients
For a long time it has been thought that the absolute best way to control glucose levels in patients with type 2 diabetes is through dieting alone. However, recent studies have uncovered that gastric bypass surgery can be more effective than dietary measures in maintaining normal levels of blood glucose. One of the results of this discovery suggests that amino acids with branched chains have an important role to play in the treatment of diabetes and the way this disease develops.
It has been observed that gastric bypass surgery improves the levels of glucose in the blood in most of the cases, but it is still not clear why this is. Obviously, the weight loss that is the result of these kinds of surgeries goes a long way towards improving the blood sugar levels of patients. However, results have been reported in many cases before the weight loss has occurred, which suggests to researchers that there is something else going on. Perhaps other chemical or biochemical pathways or hormonal triggers that have not been thoroughly studied.
A recent study has discovered that patients suffering from diabetes that have gone through gastric bypass surgery have significantly lower numbers of BCAAs in their blood (branched-chain amino acids) as well as lower levels of phenylalanine and tyrosine than patients with diabetes that lost the same weight through conventional (that is, dietary) means. This difference in the levels of branched-chain amino acids and phenylalanine and tyrosine has been linked to a better management of blood glucose levels in those patients that had the gastric bypass surgery.
What puzzles researchers is the reason why these amino acids (that have been long linked with diabetes and poor blood glucose control) were reduced so drastically in the patients with gastric bypass surgery. This suggest that there are chemical pathways and effects from certain hormones in the gastric region that have a significant effect on the metabolism. These are having an effect that is triggered by the surgery that is not present in patients that only lose weight through diet. One could even conceive that in the future, gastric bypass surgery may even become the preferred treatment for obesity in patients with type 2 diabetes, rather than a strict diet geared towards weight loss.
Branched-chain amino acids have been linked to resistance to insulin in various studies. Studies have also suggested a relationship between branched chain amino acids and coronary disease and heart disease in general. Evidence continues to grow suggesting that these kinds of substances have a link with metabolic disorders, specially diabetes and pre-diabetes. This last study suggests that a good way to reduce branched-chain amino acids in the blood is through bariatric surgery. In the future, it will be necessary to do research on the potential for these amino acids as a way to gauge possible risk for diabetes and to integrate these into existing medical practice. It is also important to understand what exactly is the pathway by which these branched-chain amino acids influence and affect blood glucose levels and their management.
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